Drug-resistant bacteria will continue to pose a growing threat unless Congress intervenes, warn experts.

Experts say the increasing public health threat of antimicrobial resistance (AMR) is already putting vulnerable patients at risk, but Congress could step in to help.

Testifying on July 11 before members of the Senate Health, Education, Labor, and Pensions Committee, Melinta Therapeutics President and CEO Christine Ann Miller noted that the issue was not far off down the road but a very present concern.

“In the United States, AMR is the third-leading cause of death behind heart disease and cancer,” said Ms. Miller, whose company develops novel antibiotics to treat antibiotic-resistant infections.

“Things have gotten worse since the pandemic in 2020,” she said. “Hospital-acquired, drug-resistant infections and deaths jumped 15 percent as COVID erased years of progress in the fight against superbugs,” or bacteria that have become resistant to antibiotics.

The source of the dilemma, Ms. Miller stated, is not a lack of innovation or regulatory red tape but a commercial marketplace problem that is “fundamentally unique to antimicrobials, driven by reimbursement and access challenges.”

Those roadblocks, she said, often drain biotech companies of their funds even after their products have been approved. However, she added that the federal government could fix the problem by enacting reimbursement reforms and implementing pull incentives to counter the risks of developing new antibiotic drugs.

Calling on Congress to step in, she added, “Every year we wait to address this crisis is another year more patients are at risk for losing their lives.”

The Fragility of Time

For Melanie Lawrence of Fairhaven, Massachusetts, the threat of antimicrobial resistance is dire as she is living with cystic fibrosis.

A progressive and incurable genetic disease, cystic fibrosis causes the body to produce thick, sticky mucus that can lead to blockages, infections, and damage to affected organs. Those born with the condition today have an estimated life expectancy of 56 years, according to the Cystic Fibrosis Foundation.

That’s why Ms. Lawrence, 43, is determined to live every moment to its fullest.

“Every day, I spend hours taking medications, doing physical therapy, exercise, meditation, breath work, all while raising a very active 12-year-old, trying to create as many meaningful memories with him as I can,” she told committee members.

After years of treatment with various antibiotics, the bacteria in Ms. Lawrence’s lungs have become resistant to nearly all antibiotics—except for tobramycin. Unfortunately, due to hearing and kidney damage, she sustained during a clinical trial, that drug is also off the table.

Now, managing her symptoms and maintaining the best possible quality of life are her goals.

“Without the security of effective antibiotics to help me heal, I find myself living with chronic fear and anxiety about when the bacteria residing in my lungs will act out or when another infection will take me away from truly living,” she said. “On a deeper level, I am often navigating a humbling loss of control, loss of autonomy, and a deep subconscious fear of death—of leaving my son without his primary caregiver, the person who knows him best and loves him without limits.”