Study: Weight loss drug linked to rare but severe stomach risk, including pancreatitis.
The new diabetes drug Ozempic, widely used for weight loss, and Wegovy, which is approved for chronic weight management in adults with obesity, have been helping thousands of people shed a significant amount of weight. However, recent evidence suggests that these medications may have rare but serious side effects.
In addition to common side effects like nausea, vomiting, and diarrhea, some users have an increased risk of three rare—but very serious—stomach conditions, according to a research letter published Thursday in the Journal of the American Medical Association (JAMA).
“The risk of severe gastrointestinal side effects is something that patients should be aware of when starting these medications,” Dr. Jessica Folek, director of bariatric surgery at Northwell Long Island Jewish Forest Hills in Queens, New York, and who was not associated with the study, told The Epoch Times.
Study Involved 16 Million Patients
Past research has shown increased risks in diabetic patients using these medications, but those patients already had higher baseline risks of gastroparesis (delayed gastric emptying) and pancreatitis.
The new population-level study examined the risk of serious stomach conditions in non-diabetic patients prescribed the class of drugs known as GLP-1s for weight loss.
GLP-1 agonists are a class of drugs that includes semaglutide, the active ingredient in Ozempic and Wegovy. These drugs work by imitating a hormone normally released in the intestines after eating which helps promote feelings of fullness and reduces appetite.
In the latest study, researchers analyzed a random sample of 16 million patient records from the PharMetrics Plus health claims database between 2006 and 2020. This database captures 93 percent of U.S. outpatient prescriptions and diagnoses.
Researchers compared the new GLP-1 drugs—semaglutide (Ozempic, Wegovy, Rybelsus), liraglutide (Saxenda, Victoza)—to the older weight loss drug bupropion-naltrexone (Contrave).
Their findings suggest GLP-1 drugs carry increased risks of three potentially severe gut conditions compared to bupropion-naltrexone.
1. Pancreatitis
Pancreatitis, an inflammation of the pancreas, causes severe abdominal pain, nausea, and vomiting.
The study found almost five cases of pancreatitis for every 1,000 people who take GLP-1 drugs, compared to only one case per 1,000 bupropion-naltrexone users.
2. Bowel Obstruction
Bowel obstruction, a blockage that interrupts the normal flow of contents through the digestive tract, causes symptoms like abdominal pain, bloating, cramping, nausea, and vomiting. The blockage may be partial or complete.
GLP-1 drug users had a four times higher risk of bowel obstruction compared to those who took bupropion-naltrexone, according to the study.
3. Gastroparesis
Gastroparesis delays stomach emptying into the small intestine, causing symptoms like nausea, vomiting, abdominal pain, and weight loss.
The study found approximately nine cases of gastroparesis per 1,000 semaglutide users, seven cases per 1,000 liraglutide users, but only three cases per 1,000 users of the older weight loss drug.
What Is the Bottom Line?
“Patients with a history of GI disorders, such as IBS [irritable bowel syndrome] may be at increased risk for these side effects,” Dr. Folek said. “So it would be worthwhile in future studies to study this as a possible contributing factor.”
However, given the superior weight loss efficacy of GLP-1 drugs and the low incidence of severe side effects (0.7-0.9 percent), these drugs remain a powerful tool for treating obesity, she noted.
The study authors acknowledged limitations, including uncertainty about whether all participants took the drugs specifically for weight loss.
The Drugs’ Manufacturer Responds
In an emailed statement to The Epoch Times, Novo Nordisk, the maker of Ozempic and Wegovy, emphasized its priority of patient safety and ongoing work with the FDA to monitor drug safety profiles.
“The FDA-approved product labeling for Novo Nordisk’s GLP-1RA medicines indicated for use in weight management (Saxenda and Wegovy) includes information about their potential side effects, including pancreatitis, acute gallbladder disease, ileus, and delayed gastric emptying,” the statement said.
Novo Nordisk also noted that similar information is included in the product labeling for their GLP-1RA diabetes medicines (Ozempic, Rybelsus, and Victoza). “Novo Nordisk stands behind the safety and efficacy of all of our GLP-1RA medicines when used consistent with the product labeling and approved indications,” the company said.
Novo Nordisk pointed out that several drugs were not on the market for much of the 2006-2020 study period. Wegovy was not yet approved, Saxenda was approved in 2014, Victoza in 2010, and Ozempic in 2017.
What precautions should healthcare professionals take when prescribing and monitoring patients using Ozempic and Wegovy, considering the potential rare but serious side effects
The new diabetes drugs Ozempic and Wegovy have gained popularity for their effectiveness in weight loss. However, recent evidence suggests that these medications may have rare but serious side effects.
According to a research letter published in the Journal of the American Medical Association (JAMA), users of these medications have an increased risk of three rare, yet severe, stomach conditions in addition to common side effects like nausea, vomiting, and diarrhea.
Dr. Jessica Folek, director of bariatric surgery at Northwell Long Island Jewish Forest Hills in New York, who was not associated with the study, emphasizes the importance of patients being aware of the potential for severe gastrointestinal side effects when starting these medications.
The study involved 16 million patients and revealed that diabetic patients using these medications already had higher baseline risks of gastroparesis (delayed gastric emptying) and pancreatitis. Previous research has also shown increased risks in diabetic patients using these drugs.
It is crucial for healthcare professionals to accurately assess the risks and benefits of these medications for individual patients. Any potential side effects should be carefully considered and discussed with patients before starting or continuing treatment.
Weight loss drugs have faced scrutiny in recent years due to their potential adverse effects. Suicidal thoughts have been identified as a dark side effect associated with certain weight loss drugs. Therefore, it is crucial for healthcare providers to closely monitor patients using these medications and ensure that appropriate steps are taken to address any potential risks.
In conclusion, while diabetes drugs like Ozempic and Wegovy have demonstrated effectiveness in weight loss, it is essential for patients and healthcare professionals to be aware of the potential rare but serious side effects associated with these medications. The decision to use these drugs should be made after careful consideration of the individual’s medical history and risk factors. Ongoing monitoring and communication between patients and healthcare providers are crucial to ensure optimal patient outcomes.
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